Protein-RNA interactions in the regulation of PTH gene expression by calcium and phosphate.
نویسندگان
چکیده
placed the weanling vitamin D-deficient rats on a diet Parathyroid hormone (PTH ) gene expression is reguwith no vitamin D, a low calcium and a low phosphate. lated transcriptionally by 23 which is able After one night of this diet, the serum phosphate had to decrease PTH transcription dramatically [1], and markedly decreased with no changes in serum calcium post-transcriptionally by calcium and phosphate [2,3]. or 23 These rats with isolated hypophosThe major effect of calcium is exerted by hypocalcaephataemia had marked decreases in PTH mRNA levels mia which regulates the parathyroid cell at a number and serum PTH. of levels and after different time periods of stimulation.
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عنوان ژورنال:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
دوره 14 4 شماره
صفحات -
تاریخ انتشار 1999